MSc. Kamil Akmermer
- A1
- Room: CS/ B 30.42/ R 111
- Phone: 48772
- Kamil akmermer ∂ kit edu
Karlsruher Institut für Technologie (KIT) - Campus Süd
Institut für Organische Chemie
Fritz-Haber-Weg 6
The aim of this work is to label peptoid-based molecular transporters with fluorescent dyes. For this purpose, Thermal Activated Delayed Fluorescence (TADF) emitters, which have proven to be promising fluorophores, should be attached to peptoids. With a theoretical internal quantum efficiency of 100%, they are thus more powerful and additionally exhibit delayed fluorescence compared to ordinary fluorescent dyes, allowing the emission to be temporally separated from the excitation light. It will be investigated to what extent the modification of the structure of the peptoids, e.g. by rigidification (cyclization) or the choice of the linked TADF emitter, has an influence on biological effects, such as cell permeability or physical properties like quantum yields, and the accessibility of chemical synthesis. One challenge is the long-lived preservation of the T1 state of the TADF emitter. This state can be quenched by oxygenic organisms. The molecular design should be chosen to suppress this process as much as possible.